Should we be taking aspirin daily to prevent heart attacks and strokes?

Aspirin is a medication we have been using for over one hundred years. At a low dose, which averages between 40-100 mg a day, aspirin has been used in the last two to three decades primarily for the prevention of heart attacks and strokes. 

We know that heart attacks and strokes can occur when cholesterol plaque in one of our major heart or brain arteries first develops, then matures (which can take decades!), and -- without warning -- becomes unstable and cracks. When it reaches this point, the blood flow over the unstable plaque recognizes the situation as “bleeding” or a “hole” in the artery. It tries to repair the situation by flowing very quickly to where it believes the problem is happening, and in the process can form a clot over the unstable plaque in less than one minute. So here we have a situation where a cholesterol plaque may only obstruct 10-20% of the opening (lumen) of a heart or brain artery. When this plaque becomes unstable, the blood forms a clot over it and within a minute there is a 100% obstruction of the blood flow. Because there is no blood flow through the artery, the cells start dying in a matter of 3 minutes for the brain and 30 minutes for the heart. This is how most heart attacks and strokes can occur. 

A low dose of aspirin works by inhibiting the sticky cells in the blood, called platelets, from sticking together and forming a clot. However, at a high dose, aspirin also inhibits various enzymes and good cells. While a low dose would protect the arteries from clotting, a higher dose would not. This is why we have been using a low dose for the prevention of heart attacks and strokes. If too much aspirin is taken, it can cause bleeding, which has the reverse effect and can encourage clotting of the arteries.  

Those who have had a heart attack or stroke are instructed to continue taking a low dose of aspirin every day for the rest of their lives. However, we must remember that science has no “last word”: it’s all based on the function of time and the evaluation of the available evidence.

So let’s say that the evidence from twenty years ago overwhelmingly supported using aspirin for the prevention of heart attacks and strokes -- not only for secondary prevention (meaning you’ve already had a heart attack or stroke and you’re taking it as a way to prevent this from happening again), but for primary prevention, which means you never had a heart attack or stroke, but you were deemed to be at a higher risk for suffering from one. This includes people with diabetes, smokers, those with high LDL or high blood pressure, a family history of heart disease, etc. For all of these people, we thought it made sense to give a low dose every day for the rest of their lives to prevent heart attacks or strokes from ever occurring in the first place.

A few months ago, science came forward and said that this is not correct. We have reevaluated the evidence, and in the modern era of medicine-- with better use of “statins” (Lipitor, Crestor, etc), medications that lower the LDL (bad cholesterol), and improved treatment of high blood pressure-- we don’t think the benefits of taking aspirin for primary prevention outweigh the risks. This is big news for patients and doctors!

Randomized trials and observations from the American College of Cardiology and the American Heart Association, which included tens of thousands of patients for years, have concluded that the use of aspirin is no longer appropriate for primary prevention of heart attacks and strokes -- except for those at very high risk (meaning those who have at least a 10% risk of developing heart attacks or strokes over the next ten years). The studies indicated that patients who have already had a heart attack or stroke should absolutely continue taking aspirin for secondary prevention. But for using aspirin for primary prevention, we have to really dive into the risk factors of the patient (age, family history, lifestyle, blood pressure level, cholesterol level) and determine if this is appropriate. Only if we evaluate these factors as being high, and the risk of bleeding from aspirin is low, then it is ok to use aspirin for primary prevention.

As with any kind of medication or regimen, please speak with your doctor before determining whether you should start or stop taking aspirin.

To your health!
Dr. Anthony

Should you integrate Eastern Medicine into your lifestyle?

Traditional Chinese Medicine (TCM), part of Eastern as distinguished from Western Medicine, has been practiced for thousands of years and focuses on HEALTH and WELL BEING through the cultivation of harmony within our lives, according to a University of Minnesota article. Concepts like ying and yang and balance as a condition of healthy living are of central importance to TCM.

While the holistic approach to wellness, health and disease is intuitively appealing, the specific methods of diagnosis and treatment that TCM uses are highly debatable. TCM methods are not subject to as rigorous a data analysis as the ones used in Western Medicine.  Biology is very complex and no statistical method can do perfect justice, whether it is Western or Eastern Medicine.

TCM includes herbs, acupuncture, massage and focusing on the whole body. Listening to one’s body is also regarded highly important. TCM leans toward prevention and wellness, not just diagnosing a problem.  According to Psychology Today, Western Medicine lies in “the newest is the best” camp. Eastern Medicine (like TCM) followers look to their doctor for experience and guidance and consider wellness a lifelong practice.

In the western world, especially in the United States, many doctors are quick to prescribe medicine. More often than not the diagnosis is not 100% determined, but doctors are trying to find a “fix”, something their patients have learned to expect or even demand. Western Medicine emphasizes the use of medications or procedures to stop the pain and suffering. Eastern Medicine practitioners claim that they want to get to the bottom of the issue- and diagnose the problem first - THEN provide a treatment. They believe that sometimes the best treatment is not a man made drug; this attitude is shared by increasingly more practitioners of Western Medicine. Additionally, more and more western physicians are embracing certain eastern practices. Acupuncture has been offered to help stop nausea and vomiting associated with surgery or chemotherapy and for chronic low back pain or even as an adjunct in attempts to quit smoking.  One US hospital has offered a chair massage before imaging examinations at their department of radiology as a way to help calm patients.  

Of course, when it comes to YOUR HEALTH - remember YOU are your own best advocate. You are free to choose a physician who keeps an open mind and is willing to embrace or try eastern medicines, if good evidence supports it. Prevention IS the best medicine, and a holistic approach is the most appropriate one; perhaps these are the principles in Chinese philosophy and TCM that merit further investigation and consideration. As long as professional organizations certify practitioners of eastern medicine using acceptable standards, why not find  a doctor willing to use TCM techniques?

One needs to consider that both Western Medicine drugs and Eastern Medicine herbals can have significant side effects and cause harm. Further scientific research is necessary to help incorporate practices of Eastern and TC Medicine into mainstream Western Medicine.

It is YOUR BODY - YOUR WELLNESS should be priority #1!

To Your health!

Dr. Anthony

Do you know what Statins are? If not, you should ….

Statins: the Pros and Cons of a Heavyweight

Statins are life saving medications, literally. In the fight against heart disease, they are credited with reversing the tide of rising heart attacks. Of course, the decline in smoking and better use of blood pressure medications has helped with the reduced rate of heart attacks. The good news is that, since 1996, for the first time in over a century, we have seen a decline in heart attacks by 40-percent.

Statins are a group of medications that lower the bad (LDL) cholesterol and reduce inflammation in our arteries. They help stabilize cholesterol plaques that frequently (and permanently) reside in our heart and brain arteries. Statins keep the blood flowing and reduce heart attacks and strokes by 30 to 40 percent.

Since statins are a true heavyweight champion of modern medicine, they are among the most widely prescribed medications in the US (almost 20 million patients use them). Although they generally have a very good safety track record, statins also have a dark side.

The greatest problem with statins is that they are not muscle friendly. About one in five statin users develops muscle aches, pains or stiffness that, although not life-threatening, can cause discomfort and suffering. To many affected statin users, these symptoms make the expected benefits not worthwhile. Other negative aspects of statin use are much more rare and include severe liver damage (one in a million), kidney failure (one in ten thousand), or type 2 diabetes (one in a thousand).

For some individuals healthy choices may include statins, on top of a  healthy lifestyle. The decision to start statins (and continue them for the rest of your life) should be based on your particular risk for developing heart attack or stroke. Individuals with the highest risk include (but are not limited to) those who have:

• already suffered a heart attack, a stroke or mini stroke
• undergone bypass surgery or stent placement
• either type 1 or type 2 diabetes
• an LDL cholesterol above 190 mg/dl.

As you discuss with your doctor whether statins are right for you, you need to weigh the good and the bad when it comes to the side effects of statins. You must consider how statins can help your arteries and prevent life-threatening conditions that may be points of no return, like heart attacks and strokes.

Keep in mind that doctors routinely check (through a simple blood test) for severe liver or muscle damage. They may also recommend over the counter supplements (like Coenzyme Q-10 or Vitamin D) that can protect against muscle aches. Doctors also warn their patients that, in case of severe muscle aches or dark-color urine, they should promptly stop taking statins.

The list of the currently available statin medications includes:

• Crestor (rosuvastatin)
• Lescol (fluvastatin)
• Lipitor (atorvastatin)
• Livalo (pitavastatin)
• Mevacor (lovastatin)
• Pravachol (pravastatin)
• Zocor (simvastatin).
• Advicor (lovastatin/niacin extended-release)
• Simcor (simvastatin/niacin extended-release)
• Vytorin (simvastatin/ezetimibe).

Good health to you!

Anthony Pothoulakis, MD, FACC

Are you self-monitoring your blood pressure?

You are as old as your arteries, even if you think you are only as old as you feel or look. And blood pressure is one of the key factors that determine your artery health. For this reason, knowing your true blood pressure is important to both you and your doctor. Many people suffer from “white coat syndrome” where they are nervous at the doctor’s office. This may result in a blood pressure measurement that is higher than your true blood pressure, whereas your home numbers are likely to be more accurate. Monitoring your blood pressure at home and on a regular basis is the best way to know your true blood pressure. This way, you will give your physician a fuller picture of your blood pressure fluctuations over an extended period of time. Also you will be an important participant to your own health care, a true partner to your doctor.

A blood pressure reading has a top number (systolic) and bottom number (diastolic). To fall into the normal range, your blood pressure should be less than 120 over 80. Prehypertension, which is borderline high blood pressure is 120-139 over 80-89. (Stage one) Mildly elevated high blood pressure is 140-159 over 90-99; and (stage two or) severely elevated high blood pressure is a reading of 160 and above over 100 and above.

Both diabetes and chronic kidney disease make your arteries more sensitive to the bad effects of high blood pressure. Many doctors believe that for these patients the blood pressure should be kept at less than 130 over 80. On the other side, for people over the age of 60, some medical professionals suggest that a top number up to 150 is acceptable. Be aware that as we age the elasticity of our aorta (the largest artery highway that starts at the heart and divides to branches that distribute the blood all over the body) declines. This declining elasticity of the aorta is frequently responsible for a low bottom number (diastolic blood pressure) observed in older individuals.

Blood pressure fluctuates all the time. It is generally higher early in the morning (its highest value is actually one to two hours before we even wake up) and between six and nine in the evening. If the blood pressure between your two arms differs by more than 10 points (mm Hg), record the higher number of the two. There are also specific factors that may cause your blood pressure to temporarily rise. For example, blood pressure rises as a result of:

• Stress
• Exercise or even ordinary physical activity at home or at work
• Caffeine
• Certain medicines
• Smoking
• Cold temperatures

Avoiding as many of these factors as you can when taking your blood pressure will help improve the accuracy of your overall numbers. Depending on the situation, your doctor may want you to check your blood pressure several times during the day to determine how wide the fluctuations are.

Before Checking Your Blood Pressure find a relatively quiet place. Make sure that you are relaxed and comfortably seated. Be sure to have recently emptied your bladder since a full bladder may affect the reading. Remove any tight-sleeved clothing or roll up the sleeve on your arm (if you are using a blood pressure cuff that fits your elbow). How and where you sit is important in an accurate reading. Before taking your blood pressure, rest in a chair next to a table for 5 minutes. Your arm should comfortably rest at heart level. Sit up straight with your back against the chair, legs uncrossed. Rest your forearm on the table with your palm facing up. If your are using a blood pressure cuff that fits your wrist, keep your wrist at the level of your heart.